N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
• CAS No.: 1263865-01-5
• Molecular Formula: C₂₄H₂₃ClN₆O
• Molecular Weight: 446.939

Synonyms:N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property of N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

There total 12 articles about N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzenamine (1235491-93-6) + 2-chloro-N-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (1263868-25-2) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-01-5)

Guidance literature:

In tetrahydrofuran; acetic acid; at 85 ℃; High-pressure vessel;

Reference yield:

2-Phenylcyclopentanone (1198-34-1) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-01-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.75 h / 58 - 130 °C

2: ammonia / water / 5 h / Heating; High-pressure flask

3: trichlorophosphate / 1 h / 110 °C / Microwave irradiation

4: tetrahydrofuran / 20 °C

5: tetrahydrofuran; acetic acid / 85 °C / High-pressure vessel

With ammonia; trichlorophosphate; In tetrahydrofuran; water; acetic acid;

Reference yield:

cyclopentanone (120-92-3) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-01-5)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / water / 4 h / 20 °C

3: 1.75 h / 58 - 130 °C

4: ammonia / water / 5 h / Heating; High-pressure flask

5: trichlorophosphate / 1 h / 110 °C / Microwave irradiation

6: tetrahydrofuran / 20 °C

7: tetrahydrofuran; acetic acid / 85 °C / High-pressure vessel

With formic acid; ammonia; dihydrogen peroxide; trichlorophosphate; In tetrahydrofuran; diethyl ether; water; acetic acid;

upstream raw materials:

cyclopentanone

phenylmagnesium bromide

2-chloro-5-nitroanisole

2-Phenylcyclopentanone

Downstream raw materials:

(R)-N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

(S)-N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

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