(2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:(2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane
CAS No.:289472-17-9
Molecular Formula:C₂₂H₃₁BrO₂Si
Molecular Weight:435.476
Hs Code.:

(2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-<i>tert</i>-butyl-dimethyl-silane

Synonyms:(2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane

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Chemical Property of (2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of (2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane

There total 6 articles about (2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [2-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-4-phenethyl-phenyl]-methanol

: 289472-17-9
(2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane

Guidance literature:: With pyridine; phosphorus tribromide; In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4039(00)00676-6

Reference yield:

: 78916-50-4
1,3-dimethoxy-5-(2-phenylethyl)benzene

: 289472-17-9
(2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: sec-BuLi; TMEDA / tetrahydrofuran

1.2: 91 percent / tetrahydrofuran

2.1: 87 percent / MgI₂*Et₂O / benzene / 3 h / Heating

3.1: NaH / tetrahydrofuran / 2 h / 20 °C

4.1: NaBH₄ / ethanol / 2.5 h / 0 °C

5.1: PBr₃; pyridine / diethyl ether / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; phosphorus tribromide; sodium hydride; magnesium iodide; In tetrahydrofuran; diethyl ether; ethanol; benzene; 1.1: Metallation / 1.2: Formylation / 2.1: demethylation / 3.1: silylation / 4.1: Reduction / 5.1: Bromination;
DOI:10.1016/S0040-4039(00)00676-6

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 289472-17-9
(2-bromomethyl-3-methoxy-5-phenethyl-phenoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 2 h / 20 °C

2: NaBH₄ / ethanol / 2.5 h / 0 °C

3: PBr₃; pyridine / diethyl ether / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; phosphorus tribromide; sodium hydride; In tetrahydrofuran; diethyl ether; ethanol; 1: silylation / 2: Reduction / 3: Bromination;
DOI:10.1016/S0040-4039(00)00676-6