ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate

Base Information

Chemical Name:ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate
CAS No.:685139-30-4
Molecular Formula:C₂₅H₂₃F₃O₄S
Molecular Weight:476.516
Hs Code.:

Synonyms:ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate

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Chemical Property of ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate

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Technology Process of ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate

There total 5 articles about ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 685139-29-1
ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

: 118486-94-5
2-(tributylstannyl)furan

: 685139-30-4
ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate

Guidance literature:: ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate; 2-(tributylstannyl)furan; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In DMF (N,N-dimethyl-formamide);

With tri-tert-butyl phosphine; In DMF (N,N-dimethyl-formamide); cyclohexane; at 50 ℃; for 1.5h;

Reference yield:

: 685139-28-0
(Z)-3-iodo-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

: 685139-30-4
ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: CBr₄; PPh₃ / CH₂Cl₂ / 0 °C

2: DIEA / CH₂Cl₂

3: Pd₂dba3; t-Bu₃P / dimethylformamide / 50 - 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbon tetrabromide; tri-tert-butyl phosphine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2007.07.164

Reference yield:

: C₁₀H₇BrF₃I

: 685139-30-4
ethyl (Z)-[4-[3-(furan-2-yl)-3-(4-trifluoromethylphenyl)allylsulfanyl]-2-methyl-phenoxy]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: DIEA / CH₂Cl₂

2: Pd₂dba3; t-Bu₃P / dimethylformamide / 50 - 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2007.07.164