ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

Base Information

Chemical Name:ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate
CAS No.:685139-29-1
Molecular Formula:C₂₁H₂₀F₃IO₃S
Molecular Weight:536.354
Hs Code.:

Synonyms:ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

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Chemical Property of ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

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Technology Process of ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

There total 5 articles about ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 685139-28-0
(Z)-3-iodo-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

: 343322-82-7
ethyl [(4-mercapto-2-methylphenyl)oxy]acetate

: 685139-29-1
ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

Guidance literature:: (Z)-3-iodo-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol; With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃;

ethyl [(4-mercapto-2-methylphenyl)oxy]acetate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; for 3h;

Reference yield:

: 173546-21-9
3-(4-trifluoromethylphenyl)prop-2-yn-1-ol

: 685139-29-1
ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran / 0 °C

1.2: AcOEt / tetrahydrofuran

1.3: I₂ / tetrahydrofuran

2.1: CBr₄; PPh₃ / CH₂Cl₂ / 0 °C

3.1: DIEA / CH₂Cl₂

With lithium aluminium tetrahydride; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 3.1: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2007.07.164

Reference yield:

: 685139-28-0
(Z)-3-iodo-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

: 685139-29-1
ethyl (Z)-(4-(3-iodo-3-(4-trifluoromethylphenyl)-prop-2-en-1-ylsulfanyl)-2-methylphenyloxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: CBr₄; PPh₃ / CH₂Cl₂ / 0 °C

2: DIEA / CH₂Cl₂

With carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2007.07.164