(2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol

Base Information

Chemical Name:(2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol
CAS No.:1141748-23-3
Molecular Formula:C₂₈H₄₆O₃Si₂
Molecular Weight:486.842
Hs Code.:

Synonyms:(2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol

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Chemical Property of (2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol

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Technology Process of (2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol

There total 7 articles about (2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1141748-39-1
C₃₈H₅₃NO₅Si₂

: 1141748-23-3
(2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; methanol; at 0 ℃; for 5h;
DOI:10.1021/ol900384u

Reference yield:

: 1192033-72-9
(2S,3S)-3-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)-2-methylpentan-1-al

: 1141748-23-3
(2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at -20 ℃; for 3h;
DOI:10.1016/j.tetlet.2015.12.051

Reference yield:

: (2R,3S)-N,N-diallyl-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentanethioamide

: 1141748-23-3
(2S,3S)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: methyl trifluoromethanesulfonate / diethyl ether / 5.5 h / 0 - 20 °C

1.2: 4 h / -78 °C

2.1: sodium tetrahydroborate / ethanol / 3 h / -20 °C

With sodium tetrahydroborate; methyl trifluoromethanesulfonate; In diethyl ether; ethanol;
DOI:10.1016/j.tetlet.2015.12.051