(R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one

Base Information

Chemical Name:(R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one
CAS No.:159142-19-5
Molecular Formula:C₃₀H₃₅NO₄Si
Molecular Weight:501.698
Hs Code.:

Synonyms:(R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one

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Chemical Property of (R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one

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Technology Process of (R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one

There total 8 articles about (R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[(R)-1-Benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-hydroxy-oxazolidin-2-one

: 159142-19-5
(R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane;
DOI:10.1039/c39940001383

Reference yield:

: 116996-52-2
(2S)-4-O-(tert-butyldiphenylsilyl)butane-1,2,4-triol

: 159142-19-5
(R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Bu₂SnO, 2.) Bu₄NBr / 1.) toluene, reflux, 4 h, 2.) 80 deg C, 24 h

2: 64.8 percent / diisopropyl azodicarboxylate, Ph₃P / tetrahydrofuran / 12 h / Ambient temperature

3: NaBH₄ / methanol / 1.) ice-cooling, 0.5 h, 2.) r.t., 2 h

4: CH₃SO₂Cl, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; di(n-butyl)tin oxide; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/P19960000793

Reference yield:

: 146028-83-3
(2S)-1,2-O-isopropylidene-4-(tert-butyldiphenylsilyl)butane-1,2,4-triol

: 159142-19-5
(R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH*H₂O / methanol / 0.5 h / Ambient temperature

2: 1.) Bu₂SnO, 2.) Bu₄NBr / 1.) toluene, reflux, 4 h, 2.) 80 deg C, 24 h

3: 64.8 percent / diisopropyl azodicarboxylate, Ph₃P / tetrahydrofuran / 12 h / Ambient temperature

4: NaBH₄ / methanol / 1.) ice-cooling, 0.5 h, 2.) r.t., 2 h

5: CH₃SO₂Cl, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; di(n-butyl)tin oxide; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/P19960000793