2-Fluoro-4-(MethoxycarbonylMethyl)benzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 2-Fluoro-4-(MethoxycarbonylMethyl)benzeneboronic acid pinacol ester, 96%
• CAS No.: 1259022-70-2
• Molecular Formula: C₁₅H₂₀BFO₄
• Molecular Weight: 294.131
• Mol file: 1259022-70-2.mol

Synonyms:methyl 2-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

Chemical Property of 2-Fluoro-4-(MethoxycarbonylMethyl)benzeneboronic acid pinacol ester, 96%

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-(methoxycarbonylmethyl)benzeneboronicAcidPinacolEster ^*data from reagent suppliers

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Technology Process of 2-Fluoro-4-(MethoxycarbonylMethyl)benzeneboronic acid pinacol ester, 96%

There total 7 articles about 2-Fluoro-4-(MethoxycarbonylMethyl)benzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 2-(4-bromo-3-fluorophenyl)acetate (942282-41-9) + bis(pinacol)diborane (73183-34-3) → methyl 2-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate (1259022-70-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 110 ℃; for 16h; Temperature; Inert atmosphere;

Reference yield: 79.0%

methyl 2-(3-fluoro-4-(((trifluoromethyl)sulfonyl)oxy)phenyl)acetate + bis(pinacol)diborane (73183-34-3) → methyl 2-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate (1259022-70-2)

Guidance literature:

With potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

Reference yield:

2-( 4-bromo-3-fluorophenyl)acetonitrile (499983-13-0) → methyl 2-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate (1259022-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; water / 16 h / 100 °C

2: thionyl chloride / 3 h / 60 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; sulfuric acid; water; potassium acetate; In 1,4-dioxane;

upstream raw materials:

bis(pinacol)diborane

4-bromo-3-fluorobenzaldehyde

4-bromo-3-fluorobenzyl alcohol

1-bromo-4-(bromomethyl)-2-fluorobenzene

Downstream raw materials:

2-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid

methyl 2-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,2'-difluorobiphenyl-4-yl)acetate

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