ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

Base Information

Chemical Name:ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate
CAS No.:148927-35-9
Molecular Formula:C₁₈H₁₂ClFN₂O₅
Molecular Weight:390.755
Hs Code.:

Synonyms:ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

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Chemical Property of ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

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Technology Process of ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

There total 7 articles about ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 161040-32-0
(Z)-2-(2,4-Dichloro-5-nitro-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid ethyl ester

: 148927-35-9
ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;
DOI:10.1021/jm00006a017

Reference yield:

: 148926-94-7
ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

: 148927-35-9
ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 3 h / Heating

2: Et₃N / dimethylformamide / 1 h / 120 - 130 °C

With triethylamine; In ethanol; N,N-dimethyl-formamide; 1: Substitution / 2: Cyclization;
DOI:10.1007/BF02464104

Reference yield:

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 148927-35-9
ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / toluene / 1 h / 90 °C

2: 85 percent / ethanol; diethyl ether / 0.25 h / Ambient temperature

3: 90 percent / K₂CO₃ / dimethylformamide / 1 h / 100 °C

With potassium carbonate; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00006a017