ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate

Base Information

• Chemical Name: ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate
• CAS No.: 1331823-97-2
• Molecular Formula: C₁₀H₈ClIN₂O₂
• Molecular Weight: 350.543
• Mol file: 1331823-97-2.mol

Synonyms:ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate

Chemical Property of ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate >95% ^*data from reagent suppliers

Safty Information:

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Technology Process of ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate

There total 4 articles about ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-chloro-3-iodopyridin-2-ylamine (417721-69-8) + ethyl Bromopyruvate (70-23-5) → ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate (1331823-97-2)

Guidance literature:

4-chloro-3-iodopyridin-2-ylamine; ethyl Bromopyruvate; In 1,2-dimethoxyethane; at 20 ℃;

In ethanol; at 78 ℃; for 2h;

DOI:10.3390/molecules170910683

Reference yield:

tert-butyl (4-chloropyridin-2-yl) carbamate (130721-78-7) → ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate (1331823-97-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 1.5 h / -70 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: hydrogen bromide / 0.17 h / 100 °C

3.1: 1,2-dimethoxyethane / 20 °C

3.2: 2 h / 78 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen bromide; In tetrahydrofuran; 1,2-dimethoxyethane; hexane;

DOI:10.3390/molecules170910683

Reference yield:

(4-chloro-3-iodopyridin-2-yl)-carbamic acid tert-butyl ester (868733-96-4) → ethyl 7-chloro-8-iodoimidazo[1,2-a]pyridine-2-carboxylate (1331823-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen bromide / 0.17 h / 100 °C

2.1: 1,2-dimethoxyethane / 20 °C

2.2: 2 h / 78 °C

With hydrogen bromide; In 1,2-dimethoxyethane;

DOI:10.3390/molecules170910683

upstream raw materials:

tert-butyl (4-chloropyridin-2-yl) carbamate

(4-chloro-3-iodopyridin-2-yl)-carbamic acid tert-butyl ester

2-Amino-4-chloropyridine

4-chloro-3-iodopyridin-2-ylamine

Downstream raw materials:

ethyl 7-(4-methoxyphenyl)-8-(p-tolylethynyl)imidazo[1,2-a]pyridine-2-carboxylate

ethyl 8-cyano-7-(p-tolylethynyl)imidazo[1,2-a]pyridine-2-carboxylate

ethyl 8-cyano-7-[4-(4-fluorophenyl)piperazin-1-yl]imidazo[1,2-a]pyridine-2-carboxylate

ethyl 7-chloro-8-(p-tolylethynyl)imidazo[1,2-a]pyridine-2-carboxylate

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