1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane

Base Information

Chemical Name:1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane
CAS No.:651300-12-8
Molecular Formula:C₅₄H₅₂N₆O₁₀
Molecular Weight:945.041
Hs Code.:

Synonyms:1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane

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Chemical Property of 1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane

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Technology Process of 1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane

There total 5 articles about 1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 560086-15-9
ethyl 2-(3-methyl-2-nitrophenyl)-1H-benzimidazole-4-carboxylate

: 560086-32-0
1,6-bis(3-bromomethylphenoxy)hexane

: 651300-12-8
1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane

Guidance literature:: ethyl 2-(3-methyl-2-nitrophenyl)-1H-benzimidazole-4-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

1,6-bis(3-bromomethylphenoxy)hexane; In tetrahydrofuran; at 50 ℃; for 16h;
DOI:10.1021/ja030196d

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 651300-12-8
1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / aq. NaOH / ethanol / 19 h / Heating

2.1: 84 percent / PBr₃ / CH₂Cl₂ / 14 h / 20 °C

3.1: NaH / tetrahydrofuran / 0 - 20 °C

3.2: 92 percent / tetrahydrofuran / 16 h / 50 °C

With sodium hydroxide; phosphorus tribromide; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja030196d

Reference yield:

: 5437-38-7
3-methyl-2-nitrobenzoic acid

: 651300-12-8
1,6-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}hexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / 20 °C

2.1: Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

2.2: 91 percent / AcONa / acetic acid / 15 h / Heating

3.1: NaH / tetrahydrofuran / 0 - 20 °C

3.2: 92 percent / tetrahydrofuran / 16 h / 50 °C

With oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja030196d