N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

Base Information

Chemical Name:N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine
CAS No.:1310123-45-5
Molecular Formula:C₅₆H₆₅N₅O₁₄Si₂
Molecular Weight:1090.31
Hs Code.:

N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

Synonyms:N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

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Chemical Property of N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

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Technology Process of N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

There total 6 articles about N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1310123-42-2
1,2,3-O-tribenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranose

: 79154-57-7
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

: 1310123-45-5
N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

Guidance literature:: 1,2,3-O-tribenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranose; With tin(IV) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h;

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine; In 1,2-dichloro-ethane; at 0 ℃; for 16h;
DOI:10.1039/c1cc11011j

Reference yield:

: 1310123-36-4
1,2,3-O-tribenzoyl-5,5-dideutero-5-O-(4-methoxyphenyldiphenylmethyl)-D-ribofuranose

: 1310123-45-5
N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; acetic acid / 16 h

2.1: pyridine / 1,2-dichloro-ethane / 1 h / 20 °C

2.2: 0.5 h

3.1: tin(IV) chloride / 1,2-dichloro-ethane / 0.17 h / 0 °C

3.2: 16 h / 0 °C

With pyridine; water; tin(IV) chloride; acetic acid; In 1,2-dichloro-ethane; 3.1: Vorbruggen glycosylation / 3.2: Vorbruggen glycosylation;
DOI:10.1039/c1cc11011j

Reference yield:

: 1310123-39-7
1,2,3-O-tribenzoyl-5,5-dideutero-D-ribofuranose

: 1310123-45-5
N(6)-benzoyl-9-[2-O-[2,3-O-dibenzoyl-5,5-dideutero-5-O-phenoxyacetyl-β-D-ribofuranosyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 0.5 h

2.1: tin(IV) chloride / 1,2-dichloro-ethane / 0.17 h / 0 °C

2.2: 16 h / 0 °C

With pyridine; tin(IV) chloride; In 1,2-dichloro-ethane; 2.1: Vorbruggen glycosylation / 2.2: Vorbruggen glycosylation;
DOI:10.1039/c1cc11011j