Technology Process of (1R,10bR)-1-<(R)-2-benzyloxy-1-hydroxyethyl>-10-methoxy-3-oxo-1,5,6,10b-tetrahydro-3H-oxazolo<4,3-a>isoquinoline
There total 11 articles about (1R,10bR)-1-<(R)-2-benzyloxy-1-hydroxyethyl>-10-methoxy-3-oxo-1,5,6,10b-tetrahydro-3H-oxazolo<4,3-a>isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: bromine / CCl4 / 3 h / 0 °C
2: dimethyl sulfoxide / 1 h / Ambient temperature
3: BH3*THF / tetrahydrofuran / 1 h / Heating
4: triethylamine / methanol / 0.5 h / Ambient temperature
5: n-butyllithium / hexane; diethyl ether / 1 h / -78 °C
6: pyridine, chromium (III) oxide, celite / CH2Cl2 / 1 h / Ambient temperature
7: potassium carbonate / methanol; H2O / 4 h / Ambient temperature
8: sodium cyanoborohydride / methanol / 1 h / 0 °C
9: 37percent hydrochloric acid / methanol; H2O / 12 h / Ambient temperature
10: 1M sodium hydroxide / CH2Cl2 / 1 h / Ambient temperature
11: 96 percent / potassium hydroxide / methanol / 0.17 h / Ambient temperature
With
pyridine; hydrogenchloride; chromium(III) oxide; potassium hydroxide; sodium hydroxide; n-butyllithium; borane-THF; Celite; bromine; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; hexane; dichloromethane; water;
DOI:10.1016/S0040-4020(01)80641-4
- Guidance literature:
-
Multi-step reaction with 7 steps
1: n-butyllithium / hexane; diethyl ether / 1 h / -78 °C
2: pyridine, chromium (III) oxide, celite / CH2Cl2 / 1 h / Ambient temperature
3: potassium carbonate / methanol; H2O / 4 h / Ambient temperature
4: sodium cyanoborohydride / methanol / 1 h / 0 °C
5: 37percent hydrochloric acid / methanol; H2O / 12 h / Ambient temperature
6: 1M sodium hydroxide / CH2Cl2 / 1 h / Ambient temperature
7: 96 percent / potassium hydroxide / methanol / 0.17 h / Ambient temperature
With
pyridine; hydrogenchloride; chromium(III) oxide; potassium hydroxide; sodium hydroxide; n-butyllithium; Celite; sodium cyanoborohydride; potassium carbonate;
In
methanol; diethyl ether; hexane; dichloromethane; water;
DOI:10.1016/S0040-4020(01)80641-4
