(E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester
CAS No.:141835-01-0
Molecular Formula:C₃₁H₃₂N₂O₄
Molecular Weight:496.606
Hs Code.:

Synonyms:(E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester

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Chemical Property of (E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester

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Technology Process of (E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester

There total 4 articles about (E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-08-2
N-Methyl-N-phenethylamine

: 141835-01-0
(E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / CH₂Cl₂ / -25 - 20 °C

2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 18 h

3: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 5 h

With sodium hydride; In dichloromethane;
DOI:10.1021/jm950699x

Reference yield:

: 92855-65-7
7-(benzyloxy)-1H-indole-3-carbaldehyde

: 141835-01-0
(E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 18 h

2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 5 h

With sodium hydride;
DOI:10.1021/jm950699x

Reference yield:

: 73391-97-6
N-methyl-N-2-phenylethyl-2-bromoacetamide

: 141835-01-0
(E)-3-{7-Benzyloxy-1-[(methyl-phenethyl-carbamoyl)-methyl]-1H-indol-3-yl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 18 h

2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 5 h

With sodium hydride;
DOI:10.1021/jm950699x