ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

Base Information

Chemical Name:ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate
CAS No.:1552320-80-5
Molecular Formula:C₁₇H₁₈ClN₃O₄S
Molecular Weight:395.867
Hs Code.:

Synonyms:ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

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Chemical Property of ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

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Technology Process of ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

There total 5 articles about ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38555-40-7
methyl 4-{[2-(methyloxy)-2-oxoethyl]thio}butanoate

: 1552320-80-5
ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / toluene / 3 h / 105 °C

2: potassium hydroxide / methanol / 16 h / 20 °C

3: water; acetic acid / 72 h / 110 °C

4: N,N-dimethyl-aniline; trichlorophosphate / 18 h / 90 °C

5: N-ethyl-N,N-diisopropylamine / ethanol / 65 h / Reflux

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

With water; sodium methylate; acetic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; trichlorophosphate; In methanol; ethanol; dichloromethane; toluene; 1: |Dieckmann Condensation;
DOI:10.1016/j.bmcl.2013.12.076

Reference yield:

: 38555-41-8
methyl 3-oxo-2,3,4,5-tetrahydro-6H-thiopyran-2-carboxylate

: 1552320-80-5
ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / 16 h / 20 °C

2: water; acetic acid / 72 h / 110 °C

3: N,N-dimethyl-aniline; trichlorophosphate / 18 h / 90 °C

4: N-ethyl-N,N-diisopropylamine / ethanol / 65 h / Reflux

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

With water; acetic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; trichlorophosphate; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.12.076

Reference yield:

: 87466-55-5
7,8-dihydro-4-hydroxy-2-methylthio-6H-thiopyrano<3,2-d>pyrimidine

: 1552320-80-5
ethyl 2-[4-[(2-chloro-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: water; acetic acid / 72 h / 110 °C

2: N,N-dimethyl-aniline; trichlorophosphate / 18 h / 90 °C

3: N-ethyl-N,N-diisopropylamine / ethanol / 65 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

With water; acetic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.12.076