N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride

Base Information

Chemical Name:N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride
CAS No.:1109229-79-9
Molecular Formula:C₃₄H₄₀F₃N₃O₃*ClH
Molecular Weight:632.166
Hs Code.:

Synonyms:N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride

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Chemical Property of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride

There total 7 articles about N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1109229-75-5
N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide

: 1109229-79-9
N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; Inert atmosphere;

Reference yield:

: 16751-59-0
4-heptylamine

: 1109229-79-9
N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: sodium sulfate / dichloromethane / 2 h / 20 °C

2: methanol; sodium tetrahydroborate / 20 °C

3: oxygen; copper diacetate / palladium diacetate / toluene / 9.5 h / Reflux

4: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 6 h / 100 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; water; oxygen; potassium acetate; copper diacetate; benzotriazol-1-ol; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium diacetate; triphenylphosphine; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1109229-76-6
N-(2-bromobenzyl)heptan-4-amine

: 1109229-79-9
N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: oxygen; copper diacetate / palladium diacetate / toluene / 9.5 h / Reflux

2: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 6 h / 100 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C / Inert atmosphere

With hydrogenchloride; water; oxygen; potassium acetate; copper diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium diacetate; triphenylphosphine; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;