16751-59-0

Basic information

• Product Name: 4-HEPTYLAMINE
• Synonyms: heptan-4-amine hydrochloride;heptan-4-ylazanium chloride;1-Propylbutanamine;1-propyl-butylamin;4-Heptanamine;Butylamine, 1-propyl-;4-HEPTYLAMINE;4-AMINOHEPTANE
• CAS NO: 16751-59-0
• Molecular Formula: C₇H₁₇N
• Molecular Weight: 115.22
• EINECS: 240-814-5
• Product Categories: Aliphatics;Amines
• Mol File: 16751-59-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: -19°C (estimate)
• Boiling Point: 140°C
• Flash Point: 41.3 °C
• Appearance: /
• Density: 0,77 g/cm3
• Vapor Pressure: 6.41mmHg at 25°C
• Refractive Index: 1.4170 to 1.4190
• PKA: 11.04±0.35(Predicted)
• CAS DataBase Reference: 4-HEPTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HEPTYLAMINE(16751-59-0)
• EPA Substance Registry System: 4-HEPTYLAMINE(16751-59-0)

Safety Data

• Hazard Codes: Xn
• Statements: 10-34-43-22
• Safety Statements: 16-26-37/39-53
• RIDADR: 2733
• WGK Germany: 3
• RTECS: EO6025000
• HazardClass: 3/8
• PackingGroup: III
• Hazardous Substances Data: 16751-59-0(Hazardous Substances Data)

Usage

Uses

4-Aminoheptane is used in organic syntheses.

InChI:InChI=1/C7H17N/c1-3-5-7(8)6-4-2/h7H,3-6,8H2,1-2H3

Upstream product

• 1188-63-2 4-heptanone oxime 
• 860571-73-9 2-propyl-valeric acid bromoamide 
• 123-19-3 4-heptanone 
• 77287-34-4 formamide 
• 40754-90-3 N-(1-propyl-n-butyl)formamide 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 
• 67-56-1 methanol 
• 19389-48-1 Butyronitrile dimer 
• 589-55-9 heptan-4-ol 
• 92326-42-6 1,2-di(heptan-4-ylidene)hydrazine 
• 71847-23-9 C₁₉H₂₆NOP 
• 540-69-2 ammonium formate 

Downstream Products

• 100-47-0 benzonitrile 
• 40754-97-0 N-4-heptylbenzamide 
• 40755-09-7 N-phenyl-N'-(1-propyl-butyl)-urea 
• 40755-05-3 1-Propyl-3-(1-propyl-butyl)-urea 
• 40318-34-1 (3,4-Dimethyl-2,6-dinitro-phenyl)-(1-propyl-butyl)-amine 
• 40754-99-2 N-p-Trifluormethylbenzoyl-4-heptylamin 
• 40754-93-6 N-Butanoyl-4-heptylamin 
• 40754-98-1 N-o-Trifluormethylbenzoyl-4-heptylamin 
• 122865-29-6 C₁₉H₂₆NO₂P 
• 868374-19-0 ethyl 2-[4-bromo-1-(2,4-dimethylphenyl)-1H-imidazole-5-carbonyl]-3-(heptan-4-ylamino)acrylate 
• 868374-55-4 (E)-2-(2,6-dichlorobenzoyl)-3-(1-propylbutylamino)acrylonitrile 
• 1109229-79-9 N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride 
• 1109229-75-5 N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide 
• 1109229-76-6 N-(2-bromobenzyl)heptan-4-amine 

Relevant articles and documents

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The dutch resolution variant of the classical resolution of racemates by formation of diastereomeric salts: Family behaviour in nucleation inhibition

The resolution of racemates through their diastereomeric salts can be positively affected by the addition of small amounts of suitable nucleation inhibitors. This discovery is a logical extension of "Dutch Resolution", in which equimolar amounts of resolving agents that are members of the same family (i.e., structurally related) are used. We conducted a systematic search for nucleation inhibitors of the resolving agent 1-phenylethylamine. A wide range of amines that bear possible family resemblances to 1-phenylethylamine was investigated. It was found that (R)-1-phenylbutylamine is a good inhibitor of (R)-1-phenylethylamine. Results of turbidity measurements showed that, for the model case of mandelic acid resolution, the chief effect of this inhibitor was to widen the metastable zone for the more soluble diastereomer. This observation is in accordance with previous experience. Further scouting for possible family members revealed a wide variation in the effectiveness of inhibitors, dependent on their structure. By far the most effective inhibitors are bifunctional 1-phenylethylamine and/or 1-phenylbutylamine analogues. The effect of racemic inhibitors was found to approach that of enantiomerically pure inhibitors of the same absolute configuration of the 1-phenylethylamine used for resolution. The most effective inhibitors were tested for the resolution of a structural variety of racemates, and were shown to be broadly applicable.

Atroposelectivity in the reactions of ortholithiated aromatic tertiary amides with aldehydes

The products of the addition of ortholithiated N,N-dialkylnaphthamides to aldehydes are pairs of stable, diastereoisomeric atropisomers, formed with selectivities of up to 90:10 in favour of the syn-atropisomer.