(2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

Base Information

Chemical Name:(2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine
CAS No.:852616-73-0
Molecular Formula:C₃₄H₃₉F₂NO₅Si
Molecular Weight:607.77
Hs Code.:

Synonyms:(2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

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Chemical Property of (2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

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Technology Process of (2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

There total 11 articles about (2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 852616-72-9
(2R,4S)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-oxo-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

: 75-61-6
dibromodifluoromethane

: 852616-73-0
(2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; zinc; In tetrahydrofuran; for 0.5h; Heating;
DOI:10.1021/jo050057+

Reference yield:

: 852616-64-9
tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

: 852616-73-0
(2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / OsO₄; 4-methylmorpholine N-oxide monohydrate / acetone; H₂O; toluene / 0 - 20 °C

2: 70 percent / DMAP; pyridine / CH₂Cl₂ / -78 - -10 °C

3: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / cooling

4: 83 percent / HMPT; Zn / tetrahydrofuran / 0.5 h / Heating

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; osmium(VIII) oxide; Dess-Martin periodane; 4-methylmorpholine 4-oxide monohydrate; zinc; In tetrahydrofuran; dichloromethane; water; acetone; toluene;
DOI:10.1021/jo050057+

Reference yield:

: 852616-66-1
tert-butyl (2R,3R,4S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-3,4-dihydroxypyrrolidine-1-carboxylate

: 852616-73-0
(2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / DMAP; pyridine / CH₂Cl₂ / -78 - -10 °C

2: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / cooling

3: 83 percent / HMPT; Zn / tetrahydrofuran / 0.5 h / Heating

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; Dess-Martin periodane; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo050057+