N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

Base Information

Chemical Name:N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide
CAS No.:871253-80-4
Molecular Formula:C₂₈H₃₇ClN₄O₂
Molecular Weight:497.08
Hs Code.:

<i>N</i>-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

Synonyms:N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

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Chemical Property of N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

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Technology Process of N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

There total 5 articles about N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 511540-39-9
(1-(4-chloro-benzyl)-2-oxo-2-{4-[1-(phenylacetylamino-methyl)-cyclohexyl]-piperazin-1-yl}-ethyl)-carbamic acid tert-butyl ester

: 871253-80-4
N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1016/j.bmcl.2005.08.061

Reference yield:

: 139754-93-1
1-(4-benzylpiperazin-1-yl)cyclohexanecarbonitrile

: 871253-80-4
N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / diethyl ether / 0.5 h / 20 °C

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 100 percent / HCO₂NH₄ / Pd-C / methanol / 0.67 h / Heating

4: 93 percent / EDC; HOBT / CH₂Cl₂ / 16 h / 20 °C

5: 100 percent / TFA / CH₂Cl₂ / 0.33 h / 20 °C

With lithium aluminium tetrahydride; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.061

Reference yield:

: 511538-96-8
(1-(4-benzylpiperazin-1-yl)cyclohexyl)methanamine

: 871253-80-4
N-(1-{4-[2-amino-3-(4-chloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / HCO₂NH₄ / Pd-C / methanol / 0.67 h / Heating

3: 93 percent / EDC; HOBT / CH₂Cl₂ / 16 h / 20 °C

4: 100 percent / TFA / CH₂Cl₂ / 0.33 h / 20 °C

With ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.061