1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Base Information

• Chemical Name: 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
• CAS No.: 1598408-33-3
• Molecular Formula: C₂₁H₂₁ClF₃N₃O₂
• Molecular Weight: 439.865
• Mol file: 1598408-33-3.mol

Synonyms:1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Chemical Property of 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

There total 5 articles about 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

C13H18N2O (1458726-10-7) + 4-chloro-3-(trifluoromethyl)phenyl isocyanate (327-78-6) → 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea (1598408-33-3)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

p-nitrocinnamoyl chloride (61921-33-3,22440-58-0) → 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea (1598408-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

2: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 6 h

3: dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

p-nitrocinnamic acid (619-89-6) → 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea (1598408-33-3)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / 0 °C / Reflux

2: triethylamine / dichloromethane / 8 h / 0 - 20 °C

3: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 6 h

4: dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.ejmech.2014.03.020

upstream raw materials:

p-nitrocinnamic acid

C₁₃H₁₈N₂O

4-chloro-3-(trifluoromethyl)phenyl isocyanate

p-nitrocinnamoyl chloride