methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate

Base Information

Chemical Name:methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate
CAS No.:1261265-98-8
Molecular Formula:C₃₆H₃₇N₃O₄
Molecular Weight:575.707
Hs Code.:

Synonyms:methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate

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Chemical Property of methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate

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Technology Process of methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate

There total 2 articles about methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

: 1239196-77-0
N-[3-methoxyphenethyl]-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide

: 114772-38-2
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

: 1261265-98-8
methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate

Guidance literature:: N-[3-methoxyphenethyl]-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide; With potassium tert-butylate; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; In N,N-dimethyl-formamide; Cooling with ice;
DOI:10.1016/j.ejmech.2012.01.009

Reference yield:

: 152628-03-0
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

: 1261265-98-8
methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 4 h / Reflux

2.1: triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

3.2: Cooling with ice

With thionyl chloride; potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.009

Reference yield: 87.8%

: 1261265-98-8
methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate

: 1261266-16-3
4'-[[4-methyl-6-(2-(3'-methoxyphenethylamino)carbonyl)-2-propyl-1H-benzimidazolyl]methyl]-2-biphenylcarboxylic acid

Guidance literature:: methyl 4'-[[6-(3'-methoxy)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate; With methanol; sodium hydroxide; for 3h; Reflux;

With hydrogenchloride; In water; pH=6;
DOI:10.1016/j.ejmech.2012.01.009