{5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester
• CAS No.: 918797-27-0
• Molecular Formula: C₆₄H₉₅N₉O₁₁
• Molecular Weight: 1166.51

Synonyms:{5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Chemical Property of {5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of {5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

There total 14 articles about {5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid (58521-49-6) → {5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester (918797-27-0)

Guidance literature:

Multi-step reaction with 7 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / CH₂Cl₂ / 20 °C

2: HCl / dioxane / 0.5 h / 20 °C

3: 257 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium-PF₆ / dimethylformamide

4: HCl / dioxane / 0.5 h / 20 °C

5: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

6: H₂ / Pd/C / methanol

7: 17 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm061033d

Reference yield:

4(S)-t-butoxycarbonylamino-N-butyl-3(S)-hydroxy-6-methylheptanamide (100002-49-1) → {5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester (918797-27-0)

Guidance literature:

Multi-step reaction with 6 steps

1: HCl / dioxane / 0.5 h / 20 °C

2: 257 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium-PF₆ / dimethylformamide

3: HCl / dioxane / 0.5 h / 20 °C

4: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

5: H₂ / Pd/C / methanol

6: 17 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm061033d

Reference yield:

(3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid butylamide → {5-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-5-[4-(6-methoxy-quinolin-8-ylamino)-pentylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester (918797-27-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 257 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium-PF₆ / dimethylformamide

2: HCl / dioxane / 0.5 h / 20 °C

3: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

4: H₂ / Pd/C / methanol

5: 17 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm061033d

upstream raw materials:

Z-Leu-OH

oxybis(benzoic acid)

(3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid

(3S,4S)-ethyl 4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoate

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