N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine

Base Information

Chemical Name:N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine
CAS No.:217325-56-9
Molecular Formula:C₂₇H₂₃Cl₂N₃O₅S
Molecular Weight:572.469
Hs Code.:

Synonyms:N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine

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Chemical Property of N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine

Chemical Property:

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Technology Process of N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine

There total 4 articles about N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-(2'-Cyano-biphenyl-4-yl)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid methyl ester

: 217325-56-9
N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(01)00705-3

Reference yield:

: 705-21-5
3,5-dichlorobenzensulfonyl chloride

: 217325-56-9
N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂CO₃ / H₂O / 20 °C

2: PyBop; iPr₂NEt / CH₂Cl₂

3: aq. LiOH / methanol; tetrahydrofuran

With lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0960-894X(01)00705-3

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 217325-56-9
N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl-(L)-4-(2'-cyanophenyl)phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂CO₃ / H₂O / 20 °C

2: PyBop; iPr₂NEt / CH₂Cl₂

3: aq. LiOH / methanol; tetrahydrofuran

With lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0960-894X(01)00705-3