1-(3-methoxyphenyl)cyclobutanecarboxylic acid

Base Information

• Chemical Name: 1-(3-methoxyphenyl)cyclobutanecarboxylic acid
• CAS No.: 74205-43-9
• Molecular Formula: C12H14 O3
• Molecular Weight: 206.24
• Hs Code.: 2918990090
• Mol file: 74205-43-9.mol

Synonyms:1-(3-Methoxyphenyl)cyclobutanecarboxylicacid

Chemical Property of 1-(3-methoxyphenyl)cyclobutanecarboxylic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.20150
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Methoxyphenyl)cyclobutane-1-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-methoxyphenyl)cyclobutanecarboxylic acid

There total 3 articles about 1-(3-methoxyphenyl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

→ 1-(3-methoxy-phenyl)-cyclobutanecarboxylic acid (74205-43-9)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 12h; Reflux;

Reference yield: 80.7%

1-(3-methoxyphenyl)cyclobutane-1-carbonitrile (74205-15-5) → 1-(3-methoxy-phenyl)-cyclobutanecarboxylic acid (74205-43-9)

Guidance literature:

With potassium hydroxide; In diethylene glycol; for 8h; Heating;

DOI:10.1007/BF00765910

Reference yield:

3-methoxyphenylacetonitrile (19924-43-7) → 1-(3-methoxy-phenyl)-cyclobutanecarboxylic acid (74205-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium amide / 1.) toluene, heating, 1 h, 2.) overnight; heating, 6 h

2: 80.7 percent / KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating

With potassium hydroxide; sodium amide; In diethylene glycol;

DOI:10.1007/BF00765910

upstream raw materials:

1-(3-methoxyphenyl)cyclobutane-1-carbonitrile

3-methoxyphenylacetonitrile

Downstream raw materials:

C₁₁H₁₂O₃

(2S,5R,6R)-6-{[1-(3-Methoxy-phenyl)-cyclobutanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

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