2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide

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Chemical Name:2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide
CAS No.:1374149-76-4
Molecular Formula:C₂₃H₂₄N₆O
Molecular Weight:400.483
Hs Code.:

Synonyms:2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide

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Chemical Property of 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide

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Technology Process of 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide

There total 5 articles about 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1374150-49-8
C₁₉H₂₀BrN₃O

: 1374149-76-4
2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide

Guidance literature:: 5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine; C₁₉H₂₀BrN₃O; With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 80 ℃; for 3h;

With sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1374149-76-4
2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 60 °C

2.1: zinc; ammonium formate / ethanol / 2 h / 50 °C

3.1: Oxone / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: triethylamine; trimethylaluminum / toluene / 0.5 h / 20 °C

4.2: 2 h / 100 °C

5.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C

With Oxone; trimethylaluminum; ammonium formate; potassium acetate; triethylamine; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1152550-37-2
4-bromo-N₁-tert-butylbenzene-1,2-diamine

: 1374149-76-4
2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Oxone / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: triethylamine; trimethylaluminum / toluene / 0.5 h / 20 °C

2.2: 2 h / 100 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C

With Oxone; trimethylaluminum; potassium acetate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;