4,5-Dihydro-4,4-dimethyl-2-(2,4,5-trifluoro-3,6-dimethylphenyl)oxazole

Base Information

Chemical Name:4,5-Dihydro-4,4-dimethyl-2-(2,4,5-trifluoro-3,6-dimethylphenyl)oxazole
CAS No.:132630-84-3
Molecular Formula:C₁₃H₁₄F₃NO
Molecular Weight:257.255
Hs Code.:
DSSTox Substance ID:DTXSID701154978
Nikkaji Number:J2.209.206E

Synonyms:SCHEMBL9089557;DTXSID701154978;132630-84-3;4,5-Dihydro-4,4-dimethyl-2-(2,4,5-trifluoro-3,6-dimethylphenyl)oxazole

Suppliers and Price of 4,5-Dihydro-4,4-dimethyl-2-(2,4,5-trifluoro-3,6-dimethylphenyl)oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-Dihydro-4,4-dimethyl-2-(2,4,5-trifluoro-3,6-dimethylphenyl)oxazole

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:257.10274856
Heavy Atom Count:18
Complexity:358

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=C(C(=C1F)F)C)F)C2=NC(CO2)(C)C

Technology Process of 4,5-Dihydro-4,4-dimethyl-2-(2,4,5-trifluoro-3,6-dimethylphenyl)oxazole

There total 7 articles about 4,5-Dihydro-4,4-dimethyl-2-(2,4,5-trifluoro-3,6-dimethylphenyl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 132630-83-2
2-(2,4,5-trifluoro-3-methylphenyl)-4,4-dimethyl-2-oxazoline

: 74-88-4
methyl iodide

: 132630-84-3
2-(2,4,5-trifluoro-3,6-dimethylphenyl)-4,4-dimethyl-2-oxazoline

Guidance literature:: 2-(2,4,5-trifluoro-3-methylphenyl)-4,4-dimethyl-2-oxazoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

methyl iodide; at -78 - 20 ℃;
DOI:10.1016/j.tet.2005.06.078

Reference yield:

: 125290-72-4
2-(2,4,5-trifluorophenyl)-4,4-dimethyl-2-oxazoline

: 132630-84-3
2-(2,4,5-trifluoro-3,6-dimethylphenyl)-4,4-dimethyl-2-oxazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 93 percent / various solvent(s) / -78 - 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 95 percent / various solvent(s) / -78 - 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2005.06.078

Reference yield:

: 125290-72-4
2-(2,4,5-trifluorophenyl)-4,4-dimethyl-2-oxazoline

: 74-88-4
methyl iodide

: 2-(3,4-difluoro-phenyl)-4,4-dimethyl-oxazoline

: 4,4-dimethyl-2-(3,4-difluoro-2-methyl-phenyl)-oxazoline

: 132630-83-2
2-(2,4,5-trifluoro-3-methylphenyl)-4,4-dimethyl-2-oxazoline

: 132630-84-3
2-(2,4,5-trifluoro-3,6-dimethylphenyl)-4,4-dimethyl-2-oxazoline

Guidance literature:: 2-(2,4,5-trifluorophenyl)-4,4-dimethyl-2-oxazoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

methyl iodide; at -78 - 20 ℃;
DOI:10.1016/j.tet.2005.06.078