(4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

Base Information

Chemical Name:(4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester
CAS No.:666831-59-0
Molecular Formula:C₃₇H₄₈O₁₁Si
Molecular Weight:696.867
Hs Code.:

(4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

Synonyms:(4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

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Chemical Property of (4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

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Technology Process of (4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

There total 1 articles about (4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 666831-45-4
(R)-4-(Dimethyl-phenyl-silanyl)-6-oxo-cyclohex-1-enecarbaldehyde

: 666831-56-7
(1S,2S)-1-((E)-(R)-2-Acetoxy-6-allyloxycarbonyl-5-oxo-hex-3-enyl)-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentanecarboxylic acid methyl ester

: 666831-59-0
(4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

Guidance literature:: With caesium carbonate; In dichloromethane; at 0 ℃; for 0.75h;
DOI:10.1021/jo0355606

Reference yield: 62.0%

: 666831-59-0
(4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

: 666831-60-3
(1S,2S)-1-{(R)-2-Acetoxy-2-[(1S,4aR,6R,8aS)-6-(dimethyl-phenyl-silanyl)-8a-formyl-3,8-dioxo-decahydro-naphthalen-1-yl]-ethyl}-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentanecarboxylic acid methyl ester

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jo0355606

Reference yield:

: 666831-59-0
(4S,4aS,7R,8aS)-4-{(R)-1-Acetoxy-2-[(1S,2S)-1-methoxycarbonyl-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentyl]-ethyl}-7-(dimethyl-phenyl-silanyl)-4a-formyl-2,5-dioxo-decahydro-naphthalene-1-carboxylic acid allyl ester

: 666831-61-4
(1S,2S)-1-{(R)-2-Acetoxy-2-[(1S,4aR,6R,8aS)-6-(dimethyl-phenyl-silanyl)-8a-hydroxymethyl-3,8-dioxo-decahydro-naphthalen-1-yl]-ethyl}-2-((R)-1-methoxy-ethyl)-5-oxo-cyclopentanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / morpholine; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

2: 72 percent / lithium tris[(3-ethyl-3-pentyl)oxy]aluminohydride / tetrahydrofuran / 22 h / -45 °C

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Lithium tris[(3-ethyl-3-pentyl)-oxy]aluminohydride; In tetrahydrofuran;
DOI:10.1021/jo0355606