2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Base Information

Chemical Name:2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside
CAS No.:142270-30-2
Molecular Formula:C₆₆H₇₇ClF₃NO₁₉Si
Molecular Weight:1308.87
Hs Code.:

2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Synonyms:2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Suppliers and Price of 2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

There total 11 articles about 2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 142270-26-6
2-(4-trifluoroacetamidophenyl)ethyl 2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

: 142270-28-8
ethyl 6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-1-thio-L-glycero-α-D-manno-heptopyranoside

: 142270-30-2
2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Guidance literature:: With 4 A molecular sieve; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; In diethyl ether; for 2h; Ambient temperature;
DOI:10.1016/S0008-6215(00)90553-6

Reference yield:

: 122588-51-6
methyl-2,3,4-tetra-O-benzyl-L-glycero-α-D-manno-heptopyranoside

: 142270-30-2
2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / 4-dimethylaminopyridine / pyridine / 2 h / Ambient temperature

2: conc. H₂SO₄ / acetic acid / 0.17 h

3: 78 percent / ZnCl₂ / CH₂Cl₂ / 3 h

4: 1) silver triflate, N-iodosuccinimide, 2) BF₃-etherate / 1) CH₂Cl₂, CH₃CN, 10 min, 2) CH₃CN, 3 h

5: 98 percent / H₂ / 10percent Pd-C / ethyl acetate / 16 h / 3000.2 Torr

6: 4-toluenesulfonic acid / acetonitrile / 0.5 h / Ambient temperature

7: pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / 2 h

8: aq. trifluoracetic acid / acetonitrile / 0.5 h

9: 73 percent / DMTST, molecular sieves 4A / diethyl ether / 2 h / Ambient temperature

With pyridine; dmap; N-iodo-succinimide; 4 A molecular sieve; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; silver trifluoromethanesulfonate; toluene-4-sulfonic acid; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; trifluoroacetic acid; zinc(II) chloride; palladium on activated charcoal; In pyridine; diethyl ether; dichloromethane; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1016/S0008-6215(00)90553-6

Reference yield:

: 142270-22-2
1,6,7-tri-O-acetyl-2,3,4-tri-O-benzyl-L-glycero-α-D-manno-heptopyranose

: 142270-30-2
2-(4-trifluoroacetamidophenyl)ethyl O-<6-O-benzoyl-2,3,4-tri-O-benzyl-7-O-(tert-butyldimethylsilyl)-L-glycero-α-D-manno-heptopyranosyl>-(1-3)-2,6,7-tri-O-acetyl-4-O-chloroacetyl-L-glycero-α-D-manno-heptopyranoside

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / ZnCl₂ / CH₂Cl₂ / 3 h

2: 1) silver triflate, N-iodosuccinimide, 2) BF₃-etherate / 1) CH₂Cl₂, CH₃CN, 10 min, 2) CH₃CN, 3 h

3: 98 percent / H₂ / 10percent Pd-C / ethyl acetate / 16 h / 3000.2 Torr

4: 4-toluenesulfonic acid / acetonitrile / 0.5 h / Ambient temperature

5: pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / 2 h

6: aq. trifluoracetic acid / acetonitrile / 0.5 h

7: 73 percent / DMTST, molecular sieves 4A / diethyl ether / 2 h / Ambient temperature

With pyridine; dmap; N-iodo-succinimide; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; silver trifluoromethanesulfonate; toluene-4-sulfonic acid; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; trifluoroacetic acid; zinc(II) chloride; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/S0008-6215(00)90553-6