4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A

Base Information

Chemical Name:4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A
CAS No.:93070-01-0
Molecular Formula:C₅₃H₆₄N₄O₁₈S₃
Molecular Weight:1141.31
Hs Code.:

Synonyms:4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A

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Chemical Property of 4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A

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Technology Process of 4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A

There total 4 articles about 4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 933-40-4
cycloxexanone dimethyl ketal

: 4'',6''-O-Benzylidene-6'-N,4'-O-carbonyl-1,3,3''-tri-N-tosylkanamycin A

: 93070-01-0
4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A

Guidance literature:: With 5A molecular sieve; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; for 6h; Heating;
DOI:10.1246/bcsj.60.713

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 93070-01-0
4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / p-toluenesulfonic acid / dimethylformamide / 37 h / Ambient temperature

2: 94 percent / sodium hydride / dimethylformamide / Ambient temperature

3: 97 percent / trifluoroacetic acid, molecular sieves 5 Angstroem / dimethylformamide; CH₂Cl₂ / 6 h / Heating

With 5A molecular sieve; sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.60.713

Reference yield:

: 76550-51-1
6'-N-(benzyloxyarbonyl)-1,3,3''-tri-N-tosylkanamycin A

: 93070-01-0
4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / p-toluenesulfonic acid / dimethylformamide / 37 h / Ambient temperature

2: 94 percent / sodium hydride / dimethylformamide / Ambient temperature

3: 97 percent / trifluoroacetic acid, molecular sieves 5 Angstroem / dimethylformamide; CH₂Cl₂ / 6 h / Heating

With 5A molecular sieve; sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.60.713