2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

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Chemical Name:2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide
CAS No.:1448439-63-1
Molecular Formula:C₂₅H₂₅N₅O₃S
Molecular Weight:475.571
Hs Code.:

Synonyms:2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

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Chemical Property of 2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

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Technology Process of 2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

There total 3 articles about 2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1448439-61-9
2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide

: 103-72-0
phenyl isothiocyanate

: 535-13-7
2-chloro-propanoic acid, ethyl ester

: 1448439-63-1
2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

Guidance literature:: 2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide; phenyl isothiocyanate; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

2-chloro-propanoic acid, ethyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.04.005

Reference yield:

: 39910-98-0
4-morpholinoacetophenone

: 1448439-63-1
2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol / 3 h / Reflux

2.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 2 h / 20 °C

With hydrogenchloride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.005

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1448439-63-1
2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / Reflux

2.1: hydrogenchloride / ethanol / 3 h / Reflux

3.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 2 h / 20 °C

With hydrogenchloride; potassium carbonate; potassium hydroxide; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.005