2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide

Base Information

• Chemical Name: 2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide
• CAS No.: 1448439-61-9
• Molecular Formula: C₁₅H₁₈N₄O₂
• Molecular Weight: 286.334
• Mol file: 1448439-61-9.mol

Synonyms:2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide

Chemical Property of 2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide

There total 2 articles about 2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-morpholinoacetophenone (39910-98-0) + Cyanoacetohydrazide (140-87-4) → 2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide (1448439-61-9)

Guidance literature:

In ethanol; for 1h; Reflux;

DOI:10.13005/ojc/310230

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide (1448439-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / Reflux

2: hydrogenchloride / ethanol / 3 h / Reflux

With hydrogenchloride; potassium carbonate; In ethanol; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2013.04.005

Reference yield: 88.0%

2-cyano-N'-(1-(4-morpholinophenyl)ethylidene)acetohydrazide (1448439-61-9) + 5-((3-bromophenyl)diazenyl)-2-hydroxybenzaldehyde → 6-((3-bromophenyl)diazenyl)-2-imino-N'-(1-(4-morpholinophenyl)ethylidene)-2H-chromene-3-carbohydrazide

Guidance literature:

With piperidine; In ethanol; for 0.5h; Reflux;

DOI:10.1002/jhet.4335

upstream raw materials:

4-morpholinoacetophenone

Cyanoacetohydrazide

1-(4-fluorophenyl)ethanone

Downstream raw materials:

2-cyano-2-(4-hydroxy-5-methyl-3-phenylthiazol-2(3H)-ylidene)-N'-(1-(4-morph-olinophenyl)ethylidene) acetohydrazide

2-cyano-2-(3,4-diphenylthiazol-2(3H)-ylidene)-N'-(1-(4-morpholinoph-enyl)ethyl-idene)acetohydrazide

4-amino-N'-(1-(4-morpholinophenyl)ethylidene)-3-phenyl-2-thioxo-2,3-dihydro-thiazole-5-carbohydrazide

4-amino-N'-(1-(4-morpholinophenyl)ethylidene)-3-(naphthalen-2-yl)-2-thioxo-2,3-dihydrothiazole-5-carbohydrazide