[4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

Base Information

Chemical Name:[4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid
CAS No.:869286-18-0
Molecular Formula:C₄₀H₆₁N₇O₁₂
Molecular Weight:831.964
Hs Code.:

[4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

Synonyms:[4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

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Chemical Property of [4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

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Technology Process of [4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

There total 2 articles about [4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 869286-20-4
[4,7-bis-tert-butoxycarbonylmethyl-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid tert-butyl ester

: 869286-18-0
[4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1039/b509230m

Reference yield:

: 497969-01-4
3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl]phenylamine

: 869286-18-0
[4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 62.26 percent / Na₂CO₃ / dioxane / 20 °C

2: 57 percent / Cs₂CO₃ / acetonitrile / 72 h / 72 °C

3: 82 percent / TFA / CH₂Cl₂ / 24 h / 20 °C

With sodium carbonate; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1039/b509230m

Reference yield: 93.0%

: terbium(III) trifluoromethanesulfonate

: 869286-18-0
[4,7-bis(carboxymethyl)-10-({3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetic acid

: 869286-26-0
[((C₂H₄N(CH₂CO₂))3C₂H₄N(CH₂CONHC₆H₃(OCH₃)N(C₂H₄O)2C₂H₄N(C₆H₄OCH₃)C₂H₄OC₂H₄))Tb(H₂O)]

Guidance literature:: In acetonitrile; ligand and Tb compd. (1.1 equiv.) were added to MeCN; soln. was freeze-pump-thawed; stirred under reflux for 24 h under Ar; cooled to room temp.; dropped slowly onto Et2O; filtered; washed (cold ether); dried (vac.);
DOI:10.1039/b509230m