4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

Base Information

Chemical Name:4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester
CAS No.:1207989-90-9
Molecular Formula:C₃₀H₃₈O₄
Molecular Weight:462.629
Hs Code.:

Synonyms:4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

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Chemical Property of 4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

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Technology Process of 4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

There total 8 articles about 4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850567-91-8
4-tert-butylcyclohex-1-en-1-ylboronic acid

: 1207989-84-1
(R)-2-(4-bromophenyl)-3-(4-(tert-butoxycarbonyl)phenyl) propanoic acid

: 1207989-90-9
4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

Guidance literature:: dichlorobis(tri-O-tolylphosphine)palladium; In 1,2-dimethoxyethane; ethanol; water; for 16h; Reflux;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1207989-90-9
4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 2 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -8 - -2 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 45 °C

3.2: 68 °C

4.1: formic acid / water; ethyl acetate / 21 °C

5.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate / ethanol; water; 1,2-dimethoxyethane / 16 h / Reflux

With formic acid; dichlorobis(tri-O-tolylphosphine)palladium; lithium hydroxide monohydrate; sulfuric acid; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate;

Reference yield:

: 121579-86-0
4-chloromethylbenzoic acid tert-butyl ester

: 1207989-90-9
4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium iodide / acetone / 2 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -8 - -2 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 45 °C

3.2: 68 °C

4.1: formic acid / water; ethyl acetate / 21 °C

5.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate / ethanol; water; 1,2-dimethoxyethane / 16 h / Reflux

With formic acid; dichlorobis(tri-O-tolylphosphine)palladium; lithium hydroxide monohydrate; sodium carbonate; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; acetone;