121579-86-0

Usage

Uses

Used in Organic Synthesis:
Tert-Butyl 4-(chloromethyl)benzoate serves as a reagent in organic synthesis, facilitating the creation of various chemical compounds due to its reactive chloromethyl group and ester functionality.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Tert-Butyl 4-(chloromethyl)benzoate is utilized as a building block for the preparation of different pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, Tert-Butyl 4-(chloromethyl)benzoate is employed as a precursor in the synthesis of various agrochemicals, contributing to the development of products for agricultural use, such as pesticides and herbicides.

InChI:InChI=1/C12H15ClO2/c1-12(2,3)15-11(14)10-6-4-9(8-13)5-7-10/h4-7H,8H2,1-3H3

Upstream product

• 1642-81-5 p-(chloromethyl)benzoic acid 
• 865-47-4 potassium tert-butylate 
• 13756-42-8 tert-butyl 4-methylbenzoate 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 

Downstream Products

• 319921-09-0 2-(4-tert-butoxycarbonyl-benzylsulfanyl)-4-methyl-pyrimidine-5-carboxylic acid 
• 845639-56-7 4-(6-chloro-4-oxopyrido[3,4-d]pyrimidin-3-ylmethyl)benzoic acid tert-butyl ester 
• 1207989-76-1 4-iodomethylbenzoic acid tert-butyl ester 
• 1207989-90-9 4-{(R)-2-[4-(4-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester 
• 1207989-84-1 (R)-2-(4-bromophenyl)-3-(4-(tert-butoxycarbonyl)phenyl) propanoic acid 
• 1207989-85-2 (R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium 
• 1207989-81-8 4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester 

Relevant academic research and scientific papers

Silver-Catalyzed C(sp3)-H Chlorination

A silver-catalyzed chlorination of benzylic, tertiary, and secondary C(sp3)-H bonds was developed. The reaction proceeded with as low as 0.2 mol % catalyst loading at room temperature under air atmosphere with synthetically useful functional group compatibility. The regioselectivity and reactivity tendencies suggest that the chlorination proceeded through a radical pathway, but an intermediate alkylsilver species cannot be ruled out.

GLUCAGON ANTAGONISTS

Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharm

GLUCAGON ANTAGONISTS

Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharm

Practical synthesis of a new analytical construct: Thiopyrimidine safety-catch linker for facile monitoring of solid-phase chemistry

We report here a new analytical construct based on a thiopyrimidine safety-catch linker. This construct adds to the existing portfolio of linkers available for facile monitoring of reactions conducted on solid support. A practical solution phase synthesis of the precursor is described, together with the proof of concept and cleavage protocols. (C) 2000 Elsevier Science Ltd.