2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

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Chemical Name:2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide
CAS No.:1022973-46-1
Molecular Formula:C₂₅H₃₄ClF₃N₆O₃S
Molecular Weight:591.098
Hs Code.:

2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Synonyms:2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

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Chemical Property of 2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

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Technology Process of 2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

There total 5 articles about 2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1648-99-3
2,2,2-Trifluoroethanesulfonyl chloride

: 1022973-44-9
N⁽⁴⁾-((1R,2R)-2-aminocyclohexyl)-5-chloro-N⁽²⁾-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]pyrimidine-2,4-diamine

: 1022973-46-1
2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1245830-90-3
(1R,2R)-N-(2,5-dichloro-pyrimidin-4-yl)cyclohexane-1,2-diamine

: 1022973-46-1
2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

2: hydrogenchloride / 1,4-dioxane; ethyl methyl ether / 120 °C

3: water; potassium hydroxide / methanol / 7 h / 60 °C

4: triethylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl methyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1022973-42-7
N-((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-2,2,2-trifluoroacetamide

: 1022973-46-1
2,2,2-trifluoroethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: water; potassium hydroxide / methanol / 7 h / 60 °C

2: triethylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With water; triethylamine; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.05.040