ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate

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Chemical Name:ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate
CAS No.:1404216-53-0
Molecular Formula:C₄₀H₆₇N₄O₅P
Molecular Weight:714.97
Hs Code.:

Synonyms:ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate

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Chemical Property of ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate

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Technology Process of ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate

There total 8 articles about ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1166948-81-7
4-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

: ethyl 3-(octadecyloxy)propyl (3-aminopropyl)phosphonate trifluoroacetic acid salt

: 1404216-53-0
ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate

Guidance literature:: 4-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde; ethyl 3-(octadecyloxy)propyl (3-aminopropyl)phosphonate trifluoroacetic acid salt; In ethanol; at 70 ℃; for 18h;

With sodium tetrahydroborate; ethanol; at 20 ℃;

Reference yield:

: 4402-24-8
diethyl 3-aminopropan-1-ylphosphonate

: 1404216-53-0
ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen bromide / water / 18 h / 90 °C / Reflux

2.1: water; methanol / 3 h / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; acetonitrile / 2 h / 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 3 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 760.05 Torr

6.1: ethanol / 18 h / 70 °C

6.2: 20 °C

With pyridine; oxalyl dichloride; hydrogen bromide; hydrogen; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1404216-49-4
(3-{[(benzyloxy)carbonyl]amino}propyl)(ethoxy)phosphinic acid triethylammonium salt

: 1404216-53-0
ethyl 3-(octadecyloxy)propyl [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)propyl]phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; acetonitrile / 2 h / 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 3 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 760.05 Torr

4.1: ethanol / 18 h / 70 °C

4.2: 20 °C

With pyridine; oxalyl dichloride; hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;