N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide

Base Information

Chemical Name:N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide
CAS No.:161314-90-5
Molecular Formula:C₂₆H₃₇N₃O₆S
Molecular Weight:519.662
Hs Code.:

Synonyms:N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide

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Chemical Property of N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide

Chemical Property:

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Technology Process of N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide

There total 9 articles about N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[dimethylaminopropyl-N'-ethylcarbodiimide hydrochloride

: 161314-97-2
2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetic acid hydrochloride

: 39684-28-1
O-(tert-butyl)hydroxylamine hydrochloride

: 161314-90-5
N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; In dichloromethane;

Reference yield:

: 3240-94-6
N-(2-chlorethyl)morpholine

: 161314-90-5
N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaOEt, 2.) KI / 1.) EtOH, reflux, 30 min, 2.) DMF, EtOH, 55 deg C, 24 h

2: 1.) 6 N aq. NaOH / 1.) EtOH, RT, 24 h, 2.) toluene, reflux, 3 h

3: 94 percent / 6 N aq. HCl / 4.5 h / Heating

4: Et₃N / dioxane; H₂O / Ambient temperature

5: toluene / 3 h / 95 °C

6: K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

7: HCl gas / CH₂Cl₂ / 4 h / Ambient temperature

8: 1-hydroxybenzotriazole, 4-methylmorpholine, N-<(dimethylamino)propyl>-N'-ethylcarbodiimide*HCl / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium ethanolate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm960871c

Reference yield:

: 161314-92-7
ethyl 2-(acetamido)-2-[2-(4-morpholino)ethyl]acetate

: 161314-90-5
N-(t-butyloxy)-2-[[4-methoxybenzenesulfonyl](benzyl)amino]-2-[2-(4-morpholino)ethyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / 6 N aq. HCl / 4.5 h / Heating

2: Et₃N / dioxane; H₂O / Ambient temperature

3: toluene / 3 h / 95 °C

4: K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

5: HCl gas / CH₂Cl₂ / 4 h / Ambient temperature

6: 1-hydroxybenzotriazole, 4-methylmorpholine, N-<(dimethylamino)propyl>-N'-ethylcarbodiimide*HCl / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm960871c