5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid

Base Information

Chemical Name:5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid
CAS No.:1598383-60-8
Molecular Formula:C₂₇H₃₈N₂O₅
Molecular Weight:470.609
Hs Code.:

Synonyms:5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid

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Chemical Property of 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid

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Technology Process of 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid

There total 7 articles about 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1598383-59-5
tert-butyl 4-((3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(methoxycarbonyl)-4-methylphenyl)ethynyl)piperidine-1-carboxylate

: 1598383-60-8
5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 60 ℃; for 6h;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1598383-60-8
5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2: ammonium chloride; ethanol; iron / water; ethyl acetate / 5 h / 80 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

6: sodium hydroxide; water / ethanol / 6 h / 60 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; water; sodium tris(acetoxy)borohydride; iron; sodium carbonate; ammonium chloride; acetic acid; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1598383-60-8
5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 5 h / 0 °C

2: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3: ammonium chloride; ethanol; iron / water; ethyl acetate / 5 h / 80 °C

4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

5: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

7: sodium hydroxide; water / ethanol / 6 h / 60 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; ethanol; sulfuric acid; water; sodium tris(acetoxy)borohydride; iron; sodium carbonate; ammonium chloride; acetic acid; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;