N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide

Base Information

Chemical Name:N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide
CAS No.:1245607-47-9
Molecular Formula:C₁₈H₁₅FN₂O₄S
Molecular Weight:374.393
Hs Code.:

Synonyms:N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide

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Chemical Property of N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide

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Technology Process of N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide

There total 5 articles about N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1245607-46-8
methyl 2-(N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)sulfamoyl)benzoate

: 1245607-47-9
N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00685

Reference yield:

: 109-00-2
3-HYDROXYPYRIDINE

: 1245607-47-9
N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

2: ammonium formate; palladium 10% on activated carbon / ethanol / 0.17 h / 90 °C / Microwave irradiation

3: pyridine / 16 h / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; palladium 10% on activated carbon; ammonium formate; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00685

Reference yield:

: 2265-94-3
1,3-difluoro-5-nitrobenzene

: 1245607-47-9
N-(3-fluoro-5-(pyridin-3-yloxy)phenyl)-2-(hydroxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

2: ammonium formate; palladium 10% on activated carbon / ethanol / 0.17 h / 90 °C / Microwave irradiation

3: pyridine / 16 h / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; palladium 10% on activated carbon; ammonium formate; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00685