(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

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Chemical Name:(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide
CAS No.:1026954-86-8
Molecular Formula:C₃₁H₄₁F₂N₅O₆
Molecular Weight:617.693
Hs Code.:

(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

Synonyms:(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

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Chemical Property of (S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

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Technology Process of (S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

There total 5 articles about (S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(1S,2R)-3,3-Difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-carbamic acid benzyl ester

: 1026954-86-8
(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 4 h / 2585.7 Torr

2: HOBT, N-methylmorpholine, EDC / tetrahydrofuran / 24 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm970250z

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 1026954-86-8
(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Et₃N / tetrahydrofuran / 1 h

2: 6.5 g / TFA / 0.5 h

3: HOBT, N-methylmorpholine, EDC / tetrahydrofuran / 24 h

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm970250z

Reference yield:

: 95500-68-8
L-valyl-L-proline tert-butyl ester

: 1026954-86-8
(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid {(1S,2R)-3,3-difluoro-2-hydroxy-1-isopropyl-3-[(pyridin-2-ylmethyl)-carbamoyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Et₃N / tetrahydrofuran / 1 h

2: 6.5 g / TFA / 0.5 h

3: HOBT, N-methylmorpholine, EDC / tetrahydrofuran / 24 h

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm970250z