2,4-Dichloro-6-iodoquinazoline

Base Information

• Chemical Name: 2,4-Dichloro-6-iodoquinazoline
• CAS No.: 74173-76-5
• Molecular Formula: C8H3 Cl2 I N2
• Molecular Weight: 324.936
• DSSTox Substance ID: DTXSID40466686
• Wikidata: Q82293300
• Mol file: 74173-76-5.mol

Synonyms:2,4-Dichloro-6-iodoquinazoline;74173-76-5;2,4-dichloro-6-iodo-quinazoline;6-Iodo-2,4-dichloroquinazoline;MFCD08543451;Quinazoline, 2,4-dichloro-6-iodo-;SCHEMBL1069650;DTXSID40466686;ZSIKVJNEGVNYIC-UHFFFAOYSA-N;AKOS015962687;PB32625;AC-17772;AS-60262;SY320982;CS-0053725;FT-0702837;P10606;A838048

Chemical Property of 2,4-Dichloro-6-iodoquinazoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 164-165 °C
• Refractive Index: 1.741
• Boiling Point: 353.266°C at 760 mmHg
• PKA: -1.11±0.30(Predicted)
• Flash Point: 167.45°C
• PSA: 25.78000
• Density: 2.083g/cm³
• LogP: 3.54120
• Storage Temp.: 2-8°C
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 323.87180
• Heavy Atom Count: 13
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-6-iodoquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1I)C(=NC(=N2)Cl)Cl

Technology Process of 2,4-Dichloro-6-iodoquinazoline

There total 12 articles about 2,4-Dichloro-6-iodoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-iodo-quinazoline-2,4-diol sodium salt (685866-85-7) → 2,4-dichloro-6-iodoquinazoline (74173-76-5)

Guidance literature:

With triethylamine hydrochloride; trichlorophosphate; at 100 ℃; for 16h; Heating / reflux;

Reference yield: 89.0%

6-Iodo-1H-quinazoline-2,4-dione (16353-27-8) → 2,4-dichloro-6-iodoquinazoline (74173-76-5)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; at 150 ℃; for 2h;

DOI:10.1021/jm00119a014

Reference yield: 87.0%

→ 2,4-dichloro-6-iodoquinazoline (74173-76-5)

Guidance literature:

upstream raw materials:

6-Iodo-1H-quinazoline-2,4-dione

5-iodoanthranilonitrile

trichloromethyl chloroformate

N-(2,4-diiodo-phenyl)-2,2,2-trifluoro-acetamide

Downstream raw materials:

6-iodo-2,4-dimethoxyquinazoline

[(2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(2,4-dimethoxy-quinazolin-6-yl)-2,5-dihydro-furan-2-yl]-methanol

6-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-quinazoline-2,4-dione

ethyl (2-chloro-6-iodo-3,4-dihydroquinazolin-3-yl)acetate