7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline

Base Information

• Chemical Name: 7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline
• CAS No.: 1437281-28-1
• Molecular Formula: C₃₂H₄₅N₃O₆Si
• Molecular Weight: 595.811
• Mol file: 1437281-28-1.mol

Synonyms:7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline

Chemical Property of 7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline

There total 8 articles about 7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.3%

di-tert-butyl dicarbonate (24424-99-5) + 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)aniline (1437281-25-8) → 7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline (1437281-28-1)

Guidance literature:

With dmap; triethylamine; for 1.5h; Reflux;

DOI:10.1021/ml4000707

Reference yield:

7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(4-nitrophenyl)-quinoxaline (1437281-24-7) → 7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline (1437281-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 0.5 h / 20 °C

2: triethylamine; dmap / 1.5 h / Reflux

With dmap; palladium on activated charcoal; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.1021/ml4000707

Reference yield:

4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline (215656-99-8) → 7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(para-di(tert-butoxycarbonyl)aminophenyl)quinoxaline (1437281-28-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 7 h / 20 °C

2.1: dimethyl sulfoxide / 2 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

4.2: 80 °C

5.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 0.5 h / 20 °C

6.1: triethylamine; dmap / 1.5 h / Reflux

With dmap; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/ml4000707

upstream raw materials:

7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(4-nitrophenyl)-quinoxaline

di-tert-butyl dicarbonate

4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)aniline

4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline

Downstream raw materials:

7-(2-hydroxyethoxy)-2-(p-di-(tert-butoxycarbonyl)aminophenyl)quinoxaline

2-((3-(4-((di-tert-butoxycarbonyl)amino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

4-(7-(2-[¹⁸F]fluoroethoxy)quinoxalin-2-yl)aniline