4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester

Base Information

• Chemical Name: 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester
• CAS No.: 863886-94-6
• Molecular Formula: C₁₄H₁₆O₇
• Molecular Weight: 296.277
• Mol file: 863886-94-6.mol

Synonyms:4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester

Chemical Property of 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester

There total 4 articles about 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-acetoxy-3-bromomethyl-benzoic acid methyl ester (117379-88-1) + glycolic acid methyl ester (96-35-5) → 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester (863886-94-6)

Guidance literature:

With silver(l) oxide; In diethyl ether; for 21.5h;

DOI:10.1039/b503802b

Reference yield:

4-acetoxy-3-methyl-benzoic acid methyl ester (863886-93-5) → 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester (863886-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / N-bromosuccinimide; AIBN / benzene / 6 h / 85 °C

2: 54 percent / Ag₂O / diethyl ether / 21.5 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver(l) oxide; In diethyl ether; benzene;

DOI:10.1039/b503802b

Reference yield:

4-hydroxy-3-methylbenzoic acid (499-76-3) → 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester (863886-94-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / SOCl₂ / 16 h / Heating

2: 76 percent / pyridine / 6 h / 22 °C

3: 79 percent / N-bromosuccinimide; AIBN / benzene / 6 h / 85 °C

4: 54 percent / Ag₂O / diethyl ether / 21.5 h

With pyridine; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); silver(l) oxide; In diethyl ether; benzene;

DOI:10.1039/b503802b

upstream raw materials:

4-acetoxy-3-bromomethyl-benzoic acid methyl ester

glycolic acid methyl ester

4-acetoxy-3-methyl-benzoic acid methyl ester

4-hydroxy-3-methylbenzoic acid