863886-93-5

Upstream product

• 5471-81-8 methyl 4-iodo-3-methylbenzoate 
• 6018-89-9 nickel(II) acetate tetrahydrate 
• 499-76-3 4-hydroxy-3-methylbenzoic acid 
• 42113-13-3 methyl 4-hydroxy-3-methylbenzoate 
• 75-36-5 acetyl chloride 

Downstream Products

• 1026288-68-5 2-(2-acetoxy-5-methoxycarbonyl-(S)-benzyloxy)-succinic acid dimethyl ester 
• 1025942-31-7 2-(2-acetoxy-5-methoxycarbonyl-(R)-benzyloxy)-succinic acid dimethyl ester 
• 863886-99-1 4-acetoxy-3-(2-methoxycarbonyl-1-methyl-allyloxymethyl)-benzoic acid methyl ester 
• 863886-98-0 4-acetoxy-3-(2-methoxycarbonyl-propoxy-(R)-methyl)-benzoic acid methyl ester 
• 863886-97-9 4-acetoxy-3-(2-methoxycarbonyl-propoxy-(S)-methyl)-benzoic acid methyl ester 
• 863886-95-7 4-acetoxy-3-(1-methoxycarbonyl-ethoxy-(S)-methyl)-benzoic acid methyl ester 
• 863886-96-8 4-acetoxy-3-(1-methoxycarbonyl-ethoxy-(R)-methyl)-benzoic acid methyl ester 
• 863886-94-6 4-acetoxy-3-(methoxycarbonyl-methoxymethyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Semi-heterogeneous Dual Nickel/Photocatalysis using Carbon Nitrides: Esterification of Carboxylic Acids with Aryl Halides

Cross-coupling reactions mediated by dual nickel/photocatalysis are synthetically attractive but rely mainly on expensive, non-recyclable noble-metal complexes as photocatalysts. Heterogeneous semiconductors, which are commonly used for artificial photosynthesis and wastewater treatment, are a sustainable alternative. Graphitic carbon nitrides, a class of metal-free polymers that can be easily prepared from bulk chemicals, are heterogeneous semiconductors with high potential for photocatalytic organic transformations. Here, we demonstrate that graphitic carbon nitrides in combination with nickel catalysis can induce selective C?O cross-couplings of carboxylic acids with aryl halides, yielding the respective aryl esters in excellent yield and selectivity. The heterogeneous organic photocatalyst exhibits a broad substrate scope, is able to harvest green light, and can be recycled multiple times. In situ FTIR was used to track the reaction progress to study this transformation at different irradiation wavelengths and reaction scales.

Design and synthesis of aromatic inhibitors of anthranilate synthase

Aromatic analogues of chorismate were synthesised as potential inhibitors of anthranilate synthase. Molecular modelling using GOLD2.1 showed that these analogues docked into the active site of Serratia marcescens anthranilate synthase in the same conformation as chorismate. Most compounds were found to be micromolar inhibitors of S. marcescens anthranilate synthase. The most potent analogue, 3-(1-carboxy-ethoxy)-4-hydroxybenzoate (K1 3 μM). included a lactyl ether side chain. This appears to be a good replacement for the enol-pyruvyl side chain of chorismate. The Royal Society of Chemistry 2005.