(Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Base Information

Chemical Name:(Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid
CAS No.:1354964-46-7
Molecular Formula:C₂₀H₁₄Cl₂N₄O₄S
Molecular Weight:477.328
Hs Code.:

Synonyms:(Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Chemical Property:

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Technology Process of (Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

There total 7 articles about (Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5461-32-5
o-nitrophenylpyruvic acid

: 1-(8,9-dichloro-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)hydrazine

: 1354964-45-6
(E)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

: 1354964-46-7
(Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Guidance literature:: With acetic acid; In ethanol; at 90 - 100 ℃; for 1h;

Reference yield:

: 5461-32-5
o-nitrophenylpyruvic acid

: 1354965-94-8
1-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)hydrazine

: 1354964-45-6
(E)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

: 1354964-46-7
(Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Guidance literature:: With acetic acid; In ethanol; at 90 - 100 ℃; for 1h;
DOI:10.1021/jm401733v

Reference yield:

: 95-50-1
1,2-dichloro-benzene

: 1354964-45-6
(E)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

: 1354964-46-7
(Z)-2-(2-(6,7-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: zinc; mercury dichloride; hydrogenchloride / water; toluene / 24 h / Reflux

3.1: polyphosphoric acid / 10 h / 130 °C

4.1: bromine / diethyl ether / 0.5 h / 20 °C

5.1: 1,4-dioxane / 49 h / 20 - 80 °C

6.1: acetic acid / ethanol / 1 h / 90 - 100 °C

With hydrogenchloride; n-butyllithium; bromine; acetic acid; mercury dichloride; zinc; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; toluene; 1.1: |Friedel-Crafts Alkylation / 2.1: |Clemmensen Reduction;
DOI:10.1021/jm401733v