N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide

Base Information

• Chemical Name: N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide
• CAS No.: 1430725-13-5
• Molecular Formula: C₂₈H₂₈F₂N₈O₂S
• Molecular Weight: 578.646
• Mol file: 1430725-13-5.mol

Synonyms:N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide

Chemical Property of N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide

There total 19 articles about N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-[1,1'-biphenyl]-3-amine (1430728-91-8) + Ethanesulfonyl chloride (594-44-5) → N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide (1430725-13-5)

Guidance literature:

With pyridine; In dichloromethane;

Reference yield:

3,5-dinitrobromobenzene (18242-39-2) → N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide (1430725-13-5)

Guidance literature:

Multi-step reaction with 12 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6: ammonium chloride; zinc / water; tetrahydrofuran / 3 h / 20 °C

7: 1 h / 90 °C

8: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

10: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; dimethyl sulfoxide / 12 h / 20 °C

11: hydrogenchloride / water / 3 h / 0 - 70 °C

12: pyridine / dichloromethane

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; iron; sodium carbonate; ammonium chloride; acetic acid; sodium L-ascorbate; triethylamine; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

meta-dinitrobenzene (99-65-0) → N-(2',4'-difluoro-5-(6-(1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-3H-imidazo[4,5-19]pyridin-3-yl)-[1,1'-biphenyl]-3-yl)ethanesulfonamide (1430725-13-5)

Guidance literature:

Multi-step reaction with 13 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 12.5 h / 0 - 20 °C

2: acetic acid; iron / acetic acid / 0.5 h / 90 °C

3: 0.5 h / 0 - 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

6: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

7: ammonium chloride; zinc / water; tetrahydrofuran / 3 h / 20 °C

8: 1 h / 90 °C

9: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

10: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

11: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; dimethyl sulfoxide / 12 h / 20 °C

12: hydrogenchloride / water / 3 h / 0 - 70 °C

13: pyridine / dichloromethane

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; iron; sodium carbonate; ammonium chloride; acetic acid; sodium L-ascorbate; triethylamine; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3,5-dinitrobromobenzene

meta-dinitrobenzene

1-amino-3-bromo-5-nitrobenzene

N-(3-bromo-5-nitrophenyl)acetamide