N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

Base Information

Chemical Name:N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide
CAS No.:169777-67-7
Molecular Formula:C₂₈H₃₇N₅O₆S
Molecular Weight:571.698
Hs Code.:

N-<4-<4-<2-<<3-<2-<N-(tert-butoxycarbonyl)amino>ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

Synonyms:N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

Suppliers and Price of N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

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Technology Process of N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

There total 6 articles about N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 169777-65-5
1-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>-4-(4-aminophenyl)piperazide

: 169777-67-7
N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

Guidance literature:: With pyridine; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm00018a020

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 169777-67-7
N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / aq. NaOH / 1 h / Ambient temperature

2: 87 percent / K₂CO₃, KI / butan-2-one / 16 h / Heating

3: 59 percent / H₂ / 10percent Pd/C / methanol / 9 h / 760 Torr / Ambient temperature

4: 90 percent / pyridine / 1 h / 0 - 20 °C

With pyridine; sodium hydroxide; hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; butanone;
DOI:10.1021/jm00018a020

Reference yield:

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 169777-67-7
N-<4-<4-<2-<<3-<2-ethyl>-1H-indol-5-yl>oxy>acetyl>piperazin-1-yl>phenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / CaCO₃ / butan-2-one / Ambient temperature

2: 87 percent / K₂CO₃, KI / butan-2-one / 16 h / Heating

3: 59 percent / H₂ / 10percent Pd/C / methanol / 9 h / 760 Torr / Ambient temperature

4: 90 percent / pyridine / 1 h / 0 - 20 °C

With pyridine; hydrogen; potassium carbonate; calcium carbonate; potassium iodide; palladium on activated charcoal; In methanol; butanone;
DOI:10.1021/jm00018a020