2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester
• CAS No.: 1195190-17-0
• Molecular Formula: C₁₈H₂₆F₂N₄O₄S
• Molecular Weight: 432.492
• Mol file: 1195190-17-0.mol

Synonyms:2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of 2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester

There total 3 articles about 2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-Dimethylacrylamide (2680-03-7,68761-83-1) + di-tert-butyl dicarbonate (24424-99-5) + 1,2-difluoro-5-isothiocyanato-3-methoxy-benzene (1195190-14-7) → 2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester (1195190-17-0)

Guidance literature:

N,N-Dimethylacrylamide; With hydrazine hydrate; In ethanol; at 20 ℃; for 2h;

di-tert-butyl dicarbonate; In ethanol; at 0 - 20 ℃;

1,2-difluoro-5-isothiocyanato-3-methoxy-benzene; In ethanol;

Reference yield:

3,4-difluoro-5-methoxyaniline (1195190-12-5) → 2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester (1195190-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 16 h / 20 °C

2.1: hydrazine hydrate / ethanol / 2 h / 20 °C

2.2: 0 - 20 °C

With hydrazine hydrate; In ethanol; dichloromethane;

Reference yield:

3,4,5-trifluoro aniline (163733-96-8) → 2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester (1195190-17-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 16 h / Reflux

2.1: dichloromethane / 16 h / 20 °C

3.1: hydrazine hydrate / ethanol / 2 h / 20 °C

3.2: 0 - 20 °C

With hydrazine hydrate; In methanol; ethanol; dichloromethane;

upstream raw materials:

N,N-Dimethylacrylamide

di-tert-butyl dicarbonate

1,2-difluoro-5-isothiocyanato-3-methoxy-benzene

3,4-difluoro-5-methoxyaniline