3,4-difluoro-5-methoxybenzenamine

Base Information

• Chemical Name: 3,4-difluoro-5-methoxybenzenamine
• CAS No.: 1195190-12-5
• Molecular Formula: C₇H₇F₂NO
• Molecular Weight: 159.135
• Hs Code.: 2921490090
• Mol file: 1195190-12-5.mol

Synonyms:3,4-difluoro-5-methoxyaniline

Chemical Property of 3,4-difluoro-5-methoxybenzenamine

Chemical Property:

• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

3,4-Difluoro-5-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3,4-Difluoro-5-methoxyaniline acts as a reagent for the preparation of azolopyrazine compounds for the treatment of infectious diseases, regioselective preparation of 3-alkoxy-4,5-difluoroanilines by nucleophilic aromatic substitution.

Technology Process of 3,4-difluoro-5-methoxybenzenamine

There total 4 articles about 3,4-difluoro-5-methoxybenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-bromo-1,2-difluoro-3-methoxy-benzene (261762-35-0) → 3,4-difluoro-5-methoxyaniline (1195190-12-5)

Guidance literature:

5-bromo-1,2-difluoro-3-methoxy-benzene; With magnesium; In tetrahydrofuran; Inert atmosphere;

With C₁₀H₁₇NO; In tetrahydrofuran; toluene; at -45 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; toluene; Inert atmosphere;

DOI:10.1038/nchem.2672

Reference yield: 77.0%

sodium methylate (124-41-4) + 3,4,5-trifluoro aniline (163733-96-8) → 3,4-difluoro-5-methoxyaniline (1195190-12-5) + C8H10FNO2 (1438272-94-6)

Guidance literature:

In methanol; for 13h; Concentration; Time; Reflux;

DOI:10.1002/ejoc.201201228

Reference yield: 77.0%

→ 3,4-difluoro-5-methoxyaniline (1195190-12-5)

Guidance literature:

With magnesium; ethylene dibromide; In tetrahydrofuran; Inert atmosphere;

With C₁₀H₁₇NO; In tetrahydrofuran; toluene; at -45 ℃; for 2h; Inert atmosphere;

upstream raw materials:

sodium methylate

3,4,5-trifluoro aniline

5-bromo-1,2-difluoro-3-methoxy-benzene

Downstream raw materials:

1,2-difluoro-5-isothiocyanato-3-methoxy-benzene

2-[[(3,4-difluoro-5-methoxyphenyl)amino]thioxomethyl]-1-[3-(dimethylamino)-3-oxopropyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester