3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile

Base Information

Chemical Name:3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile
CAS No.:1332875-76-9
Molecular Formula:C₂₂H₁₈ClF₃N₆
Molecular Weight:458.873
Hs Code.:

Synonyms:3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile

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Chemical Property of 3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile

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Technology Process of 3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile

There total 5 articles about 3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-75-8
2-chloro-6-(2-trifluoromethyl-phenyl)-pyridine-3,4-diamine

: 1332875-78-1
3-tert-butyl-4-cyanopyrazole-5-carboxylic acid chloride

: 1332875-76-9
3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile

Guidance literature:: 2-chloro-6-(2-trifluoromethyl-phenyl)-pyridine-3,4-diamine; 3-tert-butyl-4-cyanopyrazole-5-carboxylic acid chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

With trichlorophosphate; at 100 ℃; for 16h;

Reference yield:

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1332875-76-9
3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 18 h / 85 °C / Inert atmosphere

2.1: hydrogenchloride; tin(II) chloride dihdyrate / water / 90 °C

2.2: 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.2: 16 h / 100 °C

With hydrogenchloride; tin(II) chloride dihdyrate; caesium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; 1.1: Suzuki Coupling;

Reference yield:

: 84487-15-0
2-bromo-5-nitropyridin-4-amine

: 1332875-76-9
3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 18 h / 85 °C / Inert atmosphere

2.1: hydrogenchloride; tin(II) chloride dihdyrate / water / 90 °C

2.2: 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.2: 16 h / 100 °C

With hydrogenchloride; tin(II) chloride dihdyrate; caesium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; 1.1: Suzuki Coupling;