7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one

Base Information

Chemical Name:7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one
CAS No.:1393900-53-2
Molecular Formula:C₂₅H₂₅F₃N₆O
Molecular Weight:482.508
Hs Code.:

Synonyms:7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one

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Chemical Property of 7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one

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Technology Process of 7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one

There total 12 articles about 7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1393901-28-4
tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

: 1393900-53-2
7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one

Guidance literature:: tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 - 35 ℃; for 2h; Inert atmosphere;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1393900-53-2
7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-iodo-succinimide / palladium diacetate / N,N-dimethyl-formamide / 17 h / 100 °C

2.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.75 h / 0 °C / Inert atmosphere

3.1: N-Bromosuccinimide / dibenzoyl peroxide / chlorobenzene / 18 h / 90 °C

3.2: 17 h

4.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.67 h / 100 °C / microwave irradiation

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

6.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

7.1: hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 - 35 °C / Inert atmosphere

With N-Bromosuccinimide; N-iodo-succinimide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; trifluoroacetic acid; diazomethyl-trimethyl-silane; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; 10 wt% Pd(OH)2 on carbon; palladium diacetate; triphenylphosphine; dibenzoyl peroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1393900-53-2
7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 42 h / 20 °C / Inert atmosphere

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

2.2: 18 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

4.1: hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 - 35 °C / Inert atmosphere

With hydrogen; triethylamine; trifluoroacetic acid; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; triphenylphosphine; In diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;